I'd also agree with staying in Anaheim, plenty of accommodation options right near the parks and you can see a bit more on your travels. Two days was enough for me in LA proper when we were hitting the tourist highlights to tick them off. The last trip we just relaxed and explored suburbia a bit and that was nice as well. Our next trip we will explore some of the neighbourhoods that the tourist tours drive you past.
Driving is no problem once you have your "head in the game", and the great thing about LA is there is always a car in front to follow! LOL. A GPS is a must though, if possible take your own and buy the USA maps, that way you'll be used to how it gives directions. Check out some parking apps that will help identify where to park in and around LA.
Oh, buy fruit to keep in hotel room (apples, bananas and such), they arent big on veggies and fruit in meals the way we are, we wound up craving fresh stuff early in the trip.
HTH and have a fabulous trip.