Yes, you absolutely could. And that would be an excellent lesson plan!
And yes, a good teacher can take almost any book and make it relevant.
A good teacher also knows there are many, many excellent books to choose from (including this one), and will choose the one that best matches her students' interests. And that book might be TKaM, or it might be a different book entirely.
And a mediocre teacher...
I well remember, in the late 80's, one of my teachers trying to do a unit on women's rights. She taught us about sufferage in the 1920's. Bra burning in the 60's. Then she played a scratchy recording of some marching songs, and was tearing up as the voice on the tape warbled, "Our mothers were raped and murdered...!" while we all sat there uncomfortably, feeling embarrassed for her. Our consciousnesses were not raised that day!