We live in the same area as my wife's family and 2 hours drive from most of my family. My wife and I met in college and stayed in town - it just happened to be the same city that her family lived. Had no interest in moving back to where I'm from (Erie, PA), but that's not a family thing, just that the prospects of professional jobs in Erie was a lot less than in the Cleveland area.
MIL now spends 4-5 months of the year in Florida, as a snowbird, so we only see her at spring break these days. Once our boys are off to college and their own careers, we'll re-evaluate where we want to live. Right now, we're thinking we might retire early and move somewhere a little warmer - not Florida, most likely, possibly the Carolinas.